Tulku Nyima Gyaltsen Rinpoche stands at the head of one branch of a long lineage of famous Tibetan Buddhist Masters. These Masters include:
* Samantabhadra
* Vajrasattva
* Garab Dorje
* Sri Singha
* Manjushrimitra
* Jnanasutra
* Vimalamitra
* Guru Padmasambhava (Guru Rinpoche)
* Longchenpa
* Rigzin Jigme Lingpa (compiler of Longchen Nyinthig ngondro) (1729-1798)
* Jigme Gyalwai Nyugu
* Orgyen Jigme Chokyi Wangpo (Patrul Rinpoche, author of Words of My Perfect Teacher)
* Nyoshul Lungtok Tenpai Nyima (one of Patrul Rinpoche's closest students) (1829-1901/1902)
* Khenpo Ngawang Pelzang (author of Guide to the Words of My Perfect Teacher) (1879-1941)
* Tulku Arik Rinpoche (one of Khenpo Ngawang's students and Tulku Nyima's Root Lama)
* Tulku Nyima Gyaltsen Rinpoche (voice reincarnation of Khenpo Ngawang) (1942-present)